Past guests of Po Politickin include the following:

Neek Buck (Roc-a-fella Records, Young Gunz)
MMA fighter Houston Alexander
MMA fighter Shonie Carter
Curren$y (Jet Life Recordings, No Limit, Young Money)
Willy Northpole (Disturbing Tha Peace/Def Jam)
Serius Jones (MTV's all-time Fight Klub Champion/Disturbing Tha Peace)
TQ (Cash Money Records)
Needlz (Grammy Award Winning producer)
Bobby Creekwater (Shady/Aftermath)
Stat Quo (Shady/Aftermath)
Rasheeda (VH1's Love n Hip Hop Atlanta)
MC Lyte (the first solo female rapper to release a full album)
Comedian Michael Colyar
Comedian Shang
Yo Gotti (King of Memphis)
Omillio Sparks (Roc-a-Fella, G-Unit Philly)
Pornstar Nina Mercedez
Pornstar Carmen Hayes
Pornstar Kelly Divine
Pornstar Sara Jay
Short Dawg (Young Money)
Dead Prez
B.G. (Cash Money)
Fiend (No Limit)
Project Pat (3 6 Mafia)
DukedaGod (Dipset)
Hell Rell (Dipset)
Wille the Kid
Dorrough Music
Cormega
LaToiya Williams
Teedra Moses
Freddie Gibbs (CTE)
Young L (The Pak)
Nu Jersey Devil (Black Wallstreet)
Mann (Def Jam)
Glasses Malone
The Heatmakerz
Kokane
Jody Breeze (Boyz N Da Hood)
Crazy Legs (Rock Steady Crew)
Lil Wyte (Hypnotize Minds)
Brian Angel (Day 26, Bad Boy Records)
Pac Div (Universal Motown Records)
G-Dep (Bad Boy Records)
Rapper Big Pooh